New research evaluates the ability of patients with adrenal crisis to complete emergency cortisol injections

A new study sheds light on the critical ability of individuals with an adrenal crisis to complete emergency cortisol injections. This research, published in Endocrine Practice, is especially relevant to patients at National Jewish Health, where many patients are treated with steroid medications, which can cause adrenal insufficiency when used over prolonged periods.

As part of their treatment, patients are evaluated for adrenal insufficiency and are often provided with an emergency cortisol injection kit.

Adrenal insufficiency is a rare but serious condition in which the adrenal glands do not produce enough cortisol. During times of physical stress such as illness or trauma, patients are at risk of acute adrenal crisis, which requires immediate treatment with injectable glucocorticoids like hydrocortisone.

“Timely, effective intervention can mean the difference between recovery and a life-threatening situation,” said Elizabeth Regan, MD, Ph.D., a physician researcher at National Jewish Health and senior author of the study. “We must do more to ensure that patients are supported—not only with education but also with tools and systems that work when it matters most.”

A recent national survey conducted through the National Adrenal Diseases Foundation has revealed that nearly half of individuals living with adrenal insufficiency are unable to self-administer life-saving emergency injections during an adrenal crisis—a medical emergency that can rapidly become fatal without swift treatment.

“Patients are expected to act quickly and precisely during a crisis, but the very nature of the condition often prevents them from doing so,” said Dr. Regan.

The study explores the ability of patients with adrenal crisis to accurately and effectively administer emergency cortisol injections during critical situations. This new information has the potential to improve awareness and preparedness for adrenal crises, ultimately saving lives and improving the care of those at risk.